Hydrazine hydrate (1:1) → HCID 178474518、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH:9]=[CH:10][N:11](C)C)=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:19])[CH3:18].O.[NH2:21]N>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][NH:11][N:21]=2)=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:19])[CH3:18]参加物
4
実験手順
A mixture of N-[[2-chloro-5-[3-(dimethylamino)-1-oxo-2-propen-1-yl]phenyl]methyl]-acetamide (i.e. the product of Step A) (10.0 g, 35.7 mmol) and hydrazine hydrate (2.6 mL, 53.6 mmol) in methanol (100 mL) was stirred at room temperature for 20 h. The reaction mixture was then cooled to −5° C. and filtered, resulting in the title product as a solid (2.0 g), which was used in the next step without purification.
後処理
- temperatureThe reaction mixture was then cooled to −5° C.
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-1dbde14fde434928ba0da2cf1f256cf3
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921360B2
反応ノート
読み込み中…