Sodium Hydroxide → Benzofuro[3,2-d]pyrimidine-2,4(1H,3H)-dione
反応式
[C:1]([C:4]1[O:5][C:6]2[CH:18]=[CH:17][CH:16]=[CH:15][C:7]=2[C:8]=1[NH:9][C:10](=O)[O:11]CC)(=[O:3])[NH2:2].[OH-].[Na+]>CCO>[NH:9]1[C:8]2[C:7]3[CH:15]=[CH:16][CH:17]=[CH:18][C:6]=3[O:5][C:4]=2[C:1](=[O:3])[NH:2][C:10]1=[O:11]参加物
4
実験手順
Ethyl 2-carbamoylbenzofuran-3-ylcarbamate (114 mg, 0.460 mmol, 1.0 eq) in a 5% NaOH solution (3.7 mL, 4.60 mmol, 10.0 eq) and EtOH (2.2 mL) was heated to reflux for 1 h. After the mixture was cooled to room temperature, the product was precipitated by adding HCl (conc., 37%) and a solid was collected by filtration and washed with water and Et2O. This compound (40 mg, 43%) was used for the next step without further purification.
後処理
- temperatureto reflux for 1 h
- customthe product was precipitated
- additionby adding HCl (conc., 37%)
- filtrationa solid was collected by filtration
- washwashed with water and Et2O
- customThis compound (40 mg, 43%) was used for the next step without further purification
出典と根拠
- ORDレコード
- ord-95ebc1544ab749c3bc3f23d26ab596d5
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921361B2
反応ノート
読み込み中…