Trifluoroacetic acid → HCID 86657444、化合物
反応式
[C:1]([CH:5]1CC[CH:8]([OH:11])[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].N([O-])=O.[Na+].F[C:17](F)(F)[C:18]([OH:20])=[O:19]>>[C:1]([CH:5]([CH2:6][CH2:7][CH2:8][OH:11])[CH2:17][C:18]([OH:20])=[O:19])([CH3:4])([CH3:3])[CH3:2]参加物
4
実験手順
4-tert-butylcyclohexanol (10 g, 64.1 mmol) was dissolved in trifluoroacetic acid and then NaNO2 (17.09 g, 256.4 mmol) was added to the solution at 0° C. under an air. After the resulting solution was stirred at room temperature for 5 hours, the solvent was removed in vacuo at room temperature and the residue was added into an aqueous 5% NaHCO3. After the solution was treated with methylene chloride, the aqueous solution was acidified with 10% HCl solution followed by extraction with ethyl acetate to give 3-tert-butyl-6-hydroxyhexanoic acid (5.26 g, 41%).
後処理
- customthe solvent was removed in vacuo at room temperature
- additionthe residue was added into an aqueous 5% NaHCO3
- additionAfter the solution was treated with methylene chloride
- extractionfollowed by extraction with ethyl acetate
出典と根拠
- ORDレコード
- ord-984057b090934ada94af76d425469686
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921359B2
反応ノート
読み込み中…