Thionyl Chloride → HCID 58424408、化合物

反応式

[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][CH2:8][CH2:9][C:10](O)=[O:11])=[CH:4][CH:3]=1.O=S(Cl)[Cl:17]>>[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][CH2:8][CH2:9][C:10]([Cl:17])=[O:11])=[CH:4][CH:3]=1

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 23844544-(4-Bromophenoxy)butanoic acid

生成物 1

HCID 58424408HCID 58424408、化合物収率 67%

実験手順

4-(4-Bromophenoxy)butanoic acid (39 g, 25.6 mmol) was dissolved in SOCl2 (100 ml) mixture was heated to refluxed overnight. the mixture was concentrated in vacuo to give 4-(4-bromophenoxy)butanoyl chloride (27.6 g, 67%).

後処理

temperaturewas heated
temperatureto refluxed overnight
concentrationthe mixture was concentrated in vacuo

出典と根拠

ORDレコード: ord-42fd8a53005d49de871f14990f2f29aa
出典データセット: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08921359B2

反応ノート

読み込み中…

参加物