Benzyl 2,2-dimethyl-3-oxocyclopentylcarbamate → 3-Amino-2,2-dimethylcyclopentanone
反応式
[CH3:1][C:2]1([CH3:19])[C:6](=[O:7])[CH2:5][CH2:4][CH:3]1[NH:8]C(=O)OCC1C=CC=CC=1>[Pd].CO>[NH2:8][CH:3]1[CH2:4][CH2:5][C:6](=[O:7])[C:2]1([CH3:19])[CH3:1]参加物
4
実験手順
A mixture of benzyl 2,2-dimethyl-3-oxocyclopentylcarbamate (950 mg, 3.64 mmol, from Step 1) and 10% palladium on carbon (193 mg) in methanol (20 mL) was stirred under hydrogen (20 psi) for 2 h. After filtration to remove the catalyst, the filtrate was concentrated to give crude 3-amino-2,2-dimethylcyclopentanone (430 mg), which was used in the next reaction without purification.
後処理
- filtrationAfter filtration
- customto remove the catalyst
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-b6e8d076ceb749889952ee9e61566403
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921368B2
反応ノート
読み込み中…