Thionyl Chloride → HCID 58897002、化合物

HRID 1409109ノート

反応式

HRID 1409109 の反応式
[C:1]1([CH3:27])[CH:6]=[CH:5][C:4]([S:7]([N:10]2[C:14]3=[N:15][CH:16]=[CH:17][C:18]([C:19]4[CH:20]=[C:21]([CH2:25]O)[CH:22]=[CH:23][CH:24]=4)=[C:13]3[CH:12]=[CH:11]2)(=[O:9])=[O:8])=[CH:3][CH:2]=1.S(Cl)([Cl:30])=O>ClCCl>[Cl:30][CH2:25][C:21]1[CH:20]=[C:19]([C:18]2[CH:17]=[CH:16][N:15]=[C:14]3[N:10]([S:7]([C:4]4[CH:5]=[CH:6][C:1]([CH3:27])=[CH:2][CH:3]=4)(=[O:9])=[O:8])[CH:11]=[CH:12][C:13]=23)[CH:24]=[CH:23][CH:22]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 58896939HCID 58896939、化合物

生成物 1

HCID 58897002HCID 58897002、化合物収率 99.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (G) (0.25 g, 0.66 mmol) in dichloromethane (5 mL) was added thionyl chloride (0.5 mL, 6.9 mmol) at RT. The solution was allowed to stir until complete as judged by HPLC (1 hour). The solvent was removed under reduced pressure to afford 0.26 g of (H) (99% yield) as a white solid. FIA MS expected for C21H17ClN2O2S: m/e 396.07, found: 396.8 ES+. The material was used without further purification.

後処理

  1. customas judged by HPLC (1 hour)
  2. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-5efb3547f1094afc9081e0d58f457ea9
出典データセット
uspto-grants-2014_12
特許番号
US08921376B2

反応ノート

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