Potassium Carbonate → HCID 58897002、化合物

HRID 1409118ノート

反応式

HRID 1409118 の反応式
BrC1C([Cl:8])=CN=C2NC=CC=12.[C:12]1([CH3:38])[CH:17]=[CH:16][C:15]([S:18]([N:21]2[C:25]3=[N:26][CH:27]=[CH:28][C:29]([C:30]4[CH:31]=[C:32]([CH2:36]O)[CH:33]=[CH:34][CH:35]=4)=[C:24]3[CH:23]=[CH:22]2)(=[O:20])=[O:19])=[CH:14][CH:13]=1.C([O-])([O-])=O.[K+].[K+].O1CCOCC1>C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Pd].O>[Cl:8][CH2:36][C:32]1[CH:31]=[C:30]([C:29]2[CH:28]=[CH:27][N:26]=[C:25]3[N:21]([S:18]([C:15]4[CH:16]=[CH:17][C:12]([CH3:38])=[CH:13][CH:14]=4)(=[O:20])=[O:19])[CH:22]=[CH:23][C:24]=23)[CH:35]=[CH:34][CH:33]=1

参加物

7

反応物 4

HCID 11430Potassium CarbonateHCID 312751,4-DioxaneHCID 468355224-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridineHCID 58896939HCID 58896939、化合物

生成物 1

HCID 58897002HCID 58897002、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 11979704Tetrakis(triphenylphosphine)palladium溶媒

実験手順

Under N2, Compound D (1.95 g, 8.49 mmol) and compound G′ (1.1 equivalent, 9.34 mmol) and K2CO3 (3.3 equivalent, 28 mmol) were dissolved into 9 mL of dioxane and 3 mL of H2O in a microwave, to this reaction mixture, catalytic amount of Pd(Pph3)4 was added and the tube was under microwave irradiation at 170° C. for 10 min. After cooled down the reaction mixture, the product crashed out and filtered off the solid, washed with H2O and CH3CN respectively to obtain title compound H′ quantitatively. MS+1=430.5.

後処理

  1. additionwas added
  2. customthe tube was under microwave irradiation at 170° C. for 10 min
  3. temperatureAfter cooled down the reaction mixture
  4. filtrationfiltered off the solid
  5. washwashed with H2O and CH3CN respectively

出典と根拠

ORDレコード
ord-5429da1a8918421fb5b6abde8865d958
出典データセット
uspto-grants-2014_12
特許番号
US08921376B2

反応ノート

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