Diisopropylethylamine → 1-(2-Fluoro-4-methanesulfonylphenyl)-1H-imidazole-4-carboxylic acid
反応式
[NH:1]1[CH:5]=[C:4]([C:6]([OH:8])=[O:7])[N:3]=[CH:2]1.F[C:10]1[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][C:11]=1[F:20].C(N(CC)C(C)C)(C)C>CN(C)C=O>[F:20][C:11]1[CH:12]=[C:13]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:14]=[CH:15][C:10]=1[N:1]1[CH:5]=[C:4]([C:6]([OH:8])=[O:7])[N:3]=[CH:2]1参加物
5
反応条件
- 温度
- 120 °C
実験手順
A mixture of 1H-imidazole-4-carboxylic acid (500 mg), 1,2-difluoro-4-methanesulfonylbenzene (1.2 g), and N,N-diisopropyl-ethyl-amine (4 mL) in N,N-dimethylformamide (6 mL) is heated to 120° C. overnight. The crude product is purified by HPLC. LC (method 20): tR=1.69 min; Mass spectrum (APCI): m/z=285 [M+H]+.
後処理
- customThe crude product is purified by HPLC
出典と根拠
- ORDレコード
- ord-3ed85d0efecc41b0a3b6ab6f27e9acf9
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921398B2
反応ノート
読み込み中…