Lithium Hydroxide → 4-(1,3-Thiazol-2-yl)benzoic acid

HRID 14098

反応式

HRID 14098 の反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][CH:7]=1.[OH-].[Li+]>O1CCCC1.CO.O>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]([C:10]([OH:12])=[O:11])=[CH:14][CH:15]=1

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 11241445Methyl 4-(thiazol-2-Yl)benzoate

生成物 1

HCID 235104714-(1,3-Thiazol-2-yl)benzoic acid

試薬・触媒・溶媒 1

HCID 21892291Methanol tetrahydrofuran water溶媒

実験手順

To a stirred solution of methyl 4-(1,3-thiazol-2-yl)benzoate (560 mg, 2.6 mmol) in a mixture of 2:1:1 tetrahydrofuran/methanol/water (20 mL) is added lithium hydroxide (322 mg, 3 mmol). The reaction mixture is stirred at room temperature for 2 h. The solvent is removed under reduced pressure and the residue is partitioned between diethyl ether and water. The aqueous layer is acidified to pH 1 with 1 N hydrochloric acid and a precipitate is observed. The solid is collected by filtration to afford the title compound. 1H NMR (300 MHz, CD3OD) δ 8.14-8.05 (m, 4H), 7.95-7.93 (m, 1H), 7.71-7.69 (m, 1H).

後処理

  1. customThe solvent is removed under reduced pressure
  2. customthe residue is partitioned between diethyl ether and water
  3. filtrationThe solid is collected by filtration

出典と根拠

ORDレコード
ord-6c97c84963244dc1bbabfd02e6bab0a6
出典データセット
uspto-grants-2010_06
特許番号
US07727997B2

関連ノート

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