Hydrogen Bromide → 4-(2-aminoethyl)pyridin-2(1H)-one hydrobromide
反応式
Cl.C[O:3][C:4]1[CH:9]=[C:8]([CH2:10][CH2:11][NH2:12])[CH:7]=[CH:6][N:5]=1.[BrH:13]>CC(O)=O>[BrH:13].[NH2:12][CH2:11][CH2:10][C:8]1[CH:7]=[CH:6][NH:5][C:4](=[O:3])[CH:9]=1参加物
4
実験手順
A solution of 2-(2-methoxypyridin-4-yl)ethanamine hydrochloride (0.8 g, 4.23 mmol) was dissolved in 45% HBr (7 mL) and HOAc (7 mL). The mixture was heated to reflux for 4 hours and then the solvent was removed under reduce pressure. The residue was washed with THF (20 mL) and dried to give 4-(2-aminoethyl)pyridin-2(1H)-one hydrobromide (0.8 g 86%) as a grey solid. LC-MS: 139 [M+H]+, tR=0.28 min.
後処理
- temperatureThe mixture was heated
- temperatureto reflux for 4 hours
- customthe solvent was removed
- washThe residue was washed with THF (20 mL)
- customdried
出典と根拠
- ORDレコード
- ord-f3cbf7ae89d744678d639116cf720e9f
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921383B2
反応ノート
読み込み中…