Acetyl chloride → N-[1-(4-Chloro-3-nitrophenyl)ethyl]acetamide
反応式
[C:1](Cl)(=[O:3])[CH3:2].[Cl:5][C:6]1[CH:14]=[CH:13][C:9]([CH2:10][NH:11]C)=[CH:8][C:7]=1[N+:15]([O-:17])=[O:16].[C:18]([O-])(O)=O.[Na+]>C1COCC1>[Cl:5][C:6]1[CH:14]=[CH:13][C:9]([CH:10]([NH:11][C:1](=[O:3])[CH3:2])[CH3:18])=[CH:8][C:7]=1[N+:15]([O-:17])=[O:16]参加物
5
実験手順
TEA (0.28 mL, 2.0 mmol) followed by acetylchloride (96 L, 1.3 mmol) were added to 4-chloro-methyl-3-nitrobenzylamine (0.27 g, 1.3 mmol) in THF (5 mL) at rt. The mixture was stirred at rt for 3.5 h and additional acetylchloride (20 L, 0.27 mmol) was added. After 1 h at rt, NaHCO3 (aq, 5%) was added and the mixture extracted with EtOAc.
後処理
- waitAfter 1 h at rt
- extractionthe mixture extracted with EtOAc
出典と根拠
- ORDレコード
- ord-ac1fbc65b43048e3a3db36cd371872de
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921405B2
反応ノート
読み込み中…