Ammonia → Ethyl 4-amino-2-fluoro-5-nitrobenzoate
反応式
[F:1][C:2]1[CH:12]=[C:11](F)[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH3:17].O>C1COCC1>[NH2:17][C:11]1[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])=[C:2]([F:1])[CH:12]=1参加物
5
実験手順
A mixture of ethyl 2,4-difluoro-5-nitrobenzoate (5.00 g; 21.6 mmol) (see Example 59 (d)) in THF (100 mL) was treated with NH3 in THF (2.7 mL; 8 M; 21.6 mmol) at 0° C. and the mixture was stirred over night. Another portion of NH3 in THF (1.0 mL; 8M; 8 mmol) was added and the mixture stirred over night. Water (100 mL) was added and the mixture was concentrated. The precipitate was filtered off and dried to give the sub-title compound.
後処理
- stirringthe mixture stirred over night
- concentrationthe mixture was concentrated
- filtrationThe precipitate was filtered off
- customdried
出典と根拠
- ORDレコード
- ord-53bb9b409d944c3eb0194c749cb672c7
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921405B2
反応ノート
読み込み中…