2,6-Difluorobenzoic acid → Sodium 2,6-difluorobenzoate

HRID 1410429ノート

反応式

HRID 1410429 の反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:13]>CCO.O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([O-:6])=[O:5].[Na+:13]

参加物

5

反応物 2

HCID 97962,6-Difluorobenzoic acidHCID 14798Sodium Hydroxide

生成物 1

HCID 23698872Sodium 2,6-difluorobenzoate収率 100%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of 2,6-difluorobenzoic acid (1.00 g, 6.3 mmol) in EtOH and water (5:1, 60 mL) was added 1N aqueous sodium hydroxide solution (6.33 mL, 6.3 mmol). The reaction mixture was stirred for 10 minutes at room temperature and then solvents were removed in vacuo to yield sodium 2,6-difluorobenzoate (1.22 g, 6.3 mmol, quantitative) as an off white solid. 1H NMR (DMSO) δ 6.89 (2H, m), 7.15 (1H, m).

後処理

  1. customsolvents were removed in vacuo

出典と根拠

ORDレコード
ord-635760b542f24913a0acd03fb0071f95
出典データセット
uspto-grants-2014_12
特許番号
US08921544B2

反応ノート

読み込み中…