Hydrogen Bromide → 2-bromo-1-(6-bromopyridin-3-yl)ethanone
反応式
[Br:1]Br.[Br:3][C:4]1[N:9]=[CH:8][C:7]([C:10](=[O:12])[CH3:11])=[CH:6][CH:5]=1.Br>C(Cl)Cl>[Br:1][CH2:11][C:10]([C:7]1[CH:8]=[N:9][C:4]([Br:3])=[CH:5][CH:6]=1)=[O:12]参加物
5
実験手順
A solution of bromine (4 g, 25 mmol) in DCM (10 mL) was added drop wise over 5 min to a cooled (0° C.) solution of 1-(6-bromo-pyridin-3-yl)-ethanone (5 g, 25 mmol) and HBr (48%, 0.2 mL). The cooling bath was removed 40 min later and stirring was continued at RT for 66 h. The solid that formed was filtered, washed with DCM and dried at room temperature to give the impure title intermediate (8.1 g) as a yellow solid. 1H NMR (CD3OD, 400 MHz) δ (ppm): 8.96 (m, 1H), 8.28-8.25 (m, 1H), 7.82-7.79 (m, 1H), 4.7 (s, 2H).
後処理
- customThe cooling bath was removed 40 min later
- customThe solid that formed
- filtrationwas filtered
- washwashed with DCM
- customdried at room temperature
出典と根拠
- ORDレコード
- ord-ae1663aa076e4a4da10ba3a0910a2dd7
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921372B2
反応ノート
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