Ammonium Hydroxide → 6-(Trifluoromethyl)pyridazin-3-amine
反応式
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:7]=1.[OH-].[NH4+:13]>C1COCC1>[F:9][C:8]([F:11])([F:10])[C:5]1[N:4]=[N:3][C:2]([NH2:13])=[CH:7][CH:6]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
A mixture of 3-chloro-6-trifluoromethylpyridazine (1.6 g, 8.80 mmol) and ammonium hydroxide (9 mL) in THF (3 mL) was heated at 100° C. in a microwave reactor for 1 h. After this period, the reaction mixture was evaporated and the residue was extracted with dichloromethane. The combined extract was dried over with MgSO4, filtered, and evaporated under reduce pressure to afford 301a (1.3 g, 93%) as a white solid. MS-ESI: [M+H]+ 164.1
後処理
- waitAfter this period
- customthe reaction mixture was evaporated
- extractionthe residue was extracted with dichloromethane
- extractionThe combined extract
- dry with materialwas dried over with MgSO4
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-9e9fdb0f450b452a90aeaae5586db777
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921353B2
反応ノート
読み込み中…