ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Diisopropylethylamine → HCID 178495706、化合物

HRID 1413002
ノート
印刷プレビュー

反応式

HRID 1413002 の反応式
[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][N:7](C(OC(C)(C)C)=O)[C@H:6]([C:16]2[NH:17][C:18]([C:21]3[CH:26]=[C:25]4[CH2:27][O:28][C:29]5[CH:47]=[C:46]6[C:32]([CH:33]=[CH:34][C:35]7[N:39]=[C:38]([C@@H:40]8[CH2:44][CH2:43][C@H:42]([CH3:45])[NH:41]8)[NH:37][C:36]=76)=[CH:31][C:30]=5[C:24]4=[CH:23][CH:22]=3)=[CH:19][N:20]=2)[CH2:5]1.[CH3:48][O:49][C@H:50]([CH3:60])[C@H:51]([NH:55][C:56]([O:58][CH3:59])=[O:57])[C:52](O)=[O:53].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.C(=O)(O)[O-].[Na+]>CN(C=O)C>[CH3:59][O:58][C:56](=[O:57])[NH:55][C@@H:51]([C@H:50]([O:49][CH3:48])[CH3:60])[C:52]([N:41]1[C@@H:42]([CH3:45])[CH2:43][CH2:44][C@H:40]1[C:38]1[NH:37][C:36]2[C:46]3[C:32]([CH:33]=[CH:34][C:35]=2[N:39]=1)=[CH:31][C:30]1[C:24]2[C:25]([CH2:27][O:28][C:29]=1[CH:47]=3)=[CH:26][C:21]([C:18]1[NH:17][C:16]([C@@H:6]3[CH2:5][C@H:4]([CH2:3][O:2][CH3:1])[CH2:8][NH:7]3)=[N:20][CH:19]=1)=[CH:22][CH:23]=2)=[O:53]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 5

HCID 81531DiisopropylethylamineHCID 516892Sodium BicarbonateHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 59540170(2S,3R)-3-methoxy-2-(methoxycarbonylamino)butanoic acidHCID 178495689HCID 178495689、化合物

生成物 1

HCID 178495706
HCID 178495706、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of tert-butyl(2S,4S)-4-(methoxymethyl)-2-(5-{2-[(2S,5S)-5-methylpyrrolidin-2-yl]-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (101 mg, 0.159 mmol), (2S,3R)-3-methoxy-2-(methoxycarbonylamino)butanoic acid (30 mg, 0.159 mmol), HATU (61 mg, 0.159 mmol) and 2 mL 10% DIPEA in DMF was stirred at room temperature for 1.5 hours. Saturated sodium bicarbonate was added and the product was extracted into dichloromethane, dried over sodium sulphate, filtered and concentrated under reduced pressure. This crude product was treated with 5 mL 1.25N HCl in ethanol at 50° C. for 4 h and then it was concentrated under reduced pressure. Saturated sodium bicarbonate was added and the product was extracted into dichloromethane, dried over sodium sulphate, filtered and concentrated under reduced pressure. (74.6 mg)

後処理

  1. extractionthe product was extracted into dichloromethane
  2. dry with materialdried over sodium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. additionThis crude product was treated with 5 mL 1.25N HCl in ethanol at 50° C. for 4 h
  6. concentrationit was concentrated under reduced pressure
  7. additionSaturated sodium bicarbonate was added
  8. extractionthe product was extracted into dichloromethane
  9. dry with materialdried over sodium sulphate
  10. filtrationfiltered
  11. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-257ae11e8e224a97af72e338b441c329
出典データセット
uspto-grants-2014_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08921341B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート