Water → HCID 54477182、化合物

HRID 1413083ノート

反応式

HRID 1413083 の反応式
[OH:1][C@H:2]1[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8].O.[C:10](OC(=O)C)(=[O:12])[CH3:11]>N1C=CC=CC=1>[C:10]([O:1][C@H:2]1[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8])(=[O:12])[CH3:11]

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 5289581(S)-3-hydroxypiperidin-2-one

生成物 1

HCID 54477182HCID 54477182、化合物収率 89%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 460 mg of (S)-(-)-3-hydroxy-2-piperidone [A. Hunter, Biochemical Journal, 35, 1298 (1941); mp. 170°-171° C., [α]D26 =-3.0°±0.1° (c=7.027, H2O)] in 6 ml of pyridine is added 2 ml of acetic anhydride, and the mixture is allowed to stand at room temperature overnight and concentrated under reduced pressure. The residue is crystallized from ether and then recrystallized from ether to give 560 mg of (S)-(-)-3-acetoxy-2-piperidone as pillar crystals in 89% yield.

後処理

  1. concentrationconcentrated under reduced pressure
  2. customThe residue is crystallized from ether
  3. customrecrystallized from ether

出典と根拠

ORDレコード
ord-324b8e8ecaf7488990ccbd34135f998e
出典データセット
uspto-grants-1981_02
特許番号
US04248865

反応ノート

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