Thionyl Chloride → 5-chloro-4-(chloromethyl)-3-methyl-1-phenyl-1H-pyrazole

HRID 1413101ノート

反応式

HRID 1413101 の反応式
[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:13])[C:3]=1[CH2:14]O.S(Cl)([Cl:18])=O>>[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:13])[C:3]=1[CH2:14][Cl:18]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 940312(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanol

生成物 1

HCID 49627755-chloro-4-(chloromethyl)-3-methyl-1-phenyl-1H-pyrazole

実験手順

6.1 g of 5-chloro-4-hydroxymethyl-3-methyl-1-phenylpyrazole are added portionwise to 50 ml of thionylchloride. The mixture is refluxed for 2 hours, the excess thionylchloride distilled off, the oily product treated with water and then extracted with ether. The dried ethereal extract is evaporated in vacuo yielding 6.1 g of oily 5-chloro-4-chloromethyl-3-methyl-1-phenylpyrazole which, without further purification, is used in the next reaction step.

後処理

  1. temperatureThe mixture is refluxed for 2 hours
  2. distillationthe excess thionylchloride distilled off
  3. additionthe oily product treated with water
  4. extractionextracted with ether
  5. extractionThe dried ethereal extract
  6. customis evaporated in vacuo

出典と根拠

ORDレコード
ord-388b9d62d787454981ddacf6ae52855f
出典データセット
uspto-grants-1981_02
特許番号
US04248881

反応ノート

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