Salicylamide → 2-Propoxybenzamide

HRID 1413248

反応式

HRID 1413248 の反応式
[C:1]([NH2:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].C[O-].[Na+].I[CH2:15][CH2:16][CH3:17]>C(O)C>[CH2:15]([O:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]([NH2:10])=[O:9])[CH2:16][CH3:17]

参加物

5

反応物 3

HCID 5147SalicylamideHCID 336431-IodopropaneHCID 10942334Sodium Methoxide

生成物 1

HCID 430512-Propoxybenzamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A 130 gm. portion of salicylamide in 500 ml. of ethanol is reacted with 52.4 gm. of sodium methoxide and 164.9 gm. of 1-iodopropane by heating at reflux. The mixture is cooled, precipitated in 1500 ml. of water and the solid is recrystallized from hot ethanol giving o-propoxybenzamide.

後処理

  1. temperatureat reflux
  2. temperatureThe mixture is cooled
  3. customprecipitated in 1500 ml
  4. customof water and the solid is recrystallized from hot ethanol

出典と根拠

ORDレコード
ord-54406c68a1c64b7fa2be4b95cccfd99a
出典データセット
uspto-grants-1981_02
特許番号
USRE030511

関連ノート

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