Sodium Hydroxide → 2-p-Chlorophenyl-2(2,3-dibromopropionyl)5-methoxymethyl oxazolidine

HRID 1413323ノート

反応式

HRID 1413323 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[NH:12][CH2:11][CH:10]([CH2:13][O:14][CH3:15])[O:9]2)=[CH:4][CH:3]=1.[Br:16][CH:17]([CH2:21][Br:22])[C:18](Cl)=[O:19].[OH-].[Na+]>C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:18](=[O:19])[CH:17]([Br:16])[CH2:21][Br:22])[NH:12][CH2:11][CH:10]([CH2:13][O:14][CH3:15])[O:9]2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 867902,3-Dibromopropanoyl chlorideHCID 20291464p-Chlorophenyl-5-methoxymethyl oxazolidine

生成物 1

HCID 202914622-p-Chlorophenyl-2(2,3-dibromopropionyl)5-methoxymethyl oxazolidine

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To 20.8 milliliters of 25 percent w/v, p-chlorophenyl-5-methoxymethyl oxazolidine solution in 50 milliliters of benzene was added 5 grams of 2,3-dibromopropionyl chloride. To this solution was added 1.6 grams of 50% sodium hydroxide. After washing with water, drying and removal of the benzene in vacuo, there was obtained 4.8 grams of the title compound, nD30 1.5478. Analytical data supports the structure.

後処理

  1. washAfter washing with water
  2. customdrying
  3. customremoval of the benzene in vacuo

出典と根拠

ORDレコード
ord-3fb7dcb038144c808c643805cafe75c7
出典データセット
uspto-grants-1981_02
特許番号
US04249931

反応ノート

読み込み中…