Bromoacetyl bromide → 8-nitro-1(bromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine

反応式

[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]=[C:12]([NH:14][NH2:15])[CH2:11][N:10]=[C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:22])[C:8]=2[CH:23]=1)([O-:3])=[O:2].[Br:24][CH2:25][C:26](Br)=O.C([O-])(=O)C.[Na+]>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:26]([CH2:25][Br:24])=[N:15][N:14]=[C:12]3[CH2:11][N:10]=[C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:22])[C:8]=2[CH:23]=1)([O-:3])=[O:2]

参加物

反応物 3

HCID 61147Bromoacetyl bromide

HCID 517045Sodium Acetate

HCID 202918567-nitro-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine

生成物 1

HCID 202918328-nitro-1(bromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine

実験手順

In the manner given in Preparation 2, 7-nitro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl hydrazine was reacted with bromoacetyl bromide and after 1.5 hours with sodium acetate, then refluxed to give 8-nitro-1-(bromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

後処理

temperaturerefluxed

出典と根拠

ORDレコード: ord-d5f4a185bd6146cdb761fd5de0a1c109
出典データセット: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04250094

反応ノート

読み込み中…