N-bromobutanimide → 3-Bromo-2(methoxycarbonylamino)-6(phenylthio) imidazo [1,2-a] pyridine

HRID 1413429ノート

反応式

HRID 1413429 の反応式
[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:10][N:9]2[CH:21]=1)=[O:4].[Br:22]N1C(=O)CCC1=O>ClCCl>[Br:22][C:21]1[N:9]2[CH:10]=[C:11]([S:14][C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:12]=[CH:13][C:8]2=[N:7][C:6]=1[NH:5][C:3]([O:2][CH3:1])=[O:4]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 12414300Methyl [6-(phenylsulfanyl)imidazo[1,2-a]pyridin-2-yl]carbamate

生成物 1

HCID 544631513-Bromo-2(methoxycarbonylamino)-6(phenylthio) imidazo [1,2-a] pyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A suspension of 2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine (300 mg., 1 mmole) in 20 ml. of dichloromethane is treated with N-bromosuccinimide (220 mg., 1.24 mmole). The resultant solution is stirred at room temperature for 48 hours. The precipitate is collected by filtration, washed with dichloromethane and dried to yield 3-bromo-2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine m.p. 165°-168° C.

後処理

  1. filtrationThe precipitate is collected by filtration
  2. washwashed with dichloromethane
  3. customdried

出典と根拠

ORDレコード
ord-9d42bcd3f1e14f78bf75188b0907eb7e
出典データセット
uspto-grants-1981_02
特許番号
US04250174

反応ノート

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