m-Chloroperbenzoic acid → 3-Bromo-2-(methoxycarbonylamino)-6-phenylsulfinyl imidazo [1,2-a] pyridine

HRID 1413434ノート

反応式

HRID 1413434 の反応式
[Br:1][C:2]1[N:6]2[CH:7]=[C:8]([S:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[NH:18][C:19]([O:21][CH3:22])=[O:20].ClC1C=CC=C(C(OO)=[O:31])C=1>ClCCl>[Br:1][C:2]1[N:6]2[CH:7]=[C:8]([S:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[O:31])[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[NH:18][C:19]([O:21][CH3:22])=[O:20]

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 544631513-Bromo-2(methoxycarbonylamino)-6(phenylthio) imidazo [1,2-a] pyridine

生成物 1

HCID 538100123-Bromo-2-(methoxycarbonylamino)-6-phenylsulfinyl imidazo [1,2-a] pyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Alternatively, one may treat a suspension of 3-bromo-2(methoxycarbonylamino)-6(phenylthio) imidazo [1,2-a] pyridine (1.0 gm. 2.64 mmoles) in 100 ml. of dichloromethane with 85% metachloroperbenzoic acid (464 mg., 2.64 mmoles). After 1 hour at room temperature, the solution is washed with aqueous saturated sodium bicarbonate solution, and with water. After drying the solvent is removed in vacuo and the residue is chromatographed over silica gel to yield 3-bromo-2-(methoxycarbonylamino)-6-phenylsulfinyl imidazo [1,2-a] pyridine m.p. 150°-152° C.

後処理

  1. additionAlternatively, one may treat
  2. washthe solution is washed with aqueous saturated sodium bicarbonate solution
  3. customAfter drying the solvent
  4. customis removed in vacuo
  5. customthe residue is chromatographed over silica gel

出典と根拠

ORDレコード
ord-9b47318919064db39001fc0a3072aa2a
出典データセット
uspto-grants-1981_02
特許番号
US04250174

反応ノート

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