Ammonia → HCID 178456690、化合物

反応式

[CH:1]([N:4]([C:6]#[N:7])[NH2:5])([CH3:3])[CH3:2].C(Cl)([Cl:10])=O.N.[O:13]1[CH2:17]CCC1>>[CH:1]([N:4]1[C:6]([Cl:10])=[N:7][C:17]([OH:13])=[N:5]1)([CH3:3])[CH3:2]

参加物

反応物 4

HCID 222Ammonia

HCID 6371Phosgene

HCID 8028Tetrahydrofuran

HCID 94131Hydrazinecarbonitrile, 1-(1-methylethyl)-

生成物 1

HCID 178456690HCID 178456690、化合物

実験手順

A preferred embodiment of the improved process according to the present invention comprises reacting 1-isopropyl-1-cyanohydrazine in the form of a 6-8 percent solution in tetrahydrofuran with phosgene at a temperature of between 0°-30° C., treating the reaction mixture with anhydrous ammonia to form the ammonium salt of 1-isopropyl-3-hydroxy-5-chloro-1,2,4-triazole, which precipitates almost totally from the tetrahydrofuran reaction mass, and liberating from said isolated salt 1-isopropyl-3-hydroxy-5-chloro-1,2,4-triazole in a yield ranging from 85.8-92.1% of theory and in a very pure state, such as of 98% assay, by treating it with 32-37% hydrochloric acid.