Hydrogen Bromide → 1-(Chloromethyl)adamantane

HRID 1414200

反応式

HRID 1414200 の反応式
[C:1]12([CH2:11]O)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.C12(CBr)CC3CC(CC(C3)C1)C2.Br.[ClH:26]>[Br-].[Zn+2].[Br-].[Cl-].[Zn+2].[Cl-]>[C:1]12([CH2:11][Cl:26])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

参加物

7

反応物 4

HCID 260Hydrogen BromideHCID 313Hydrochloric AcidHCID 64556Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol2 回HCID 14163041-(Bromomethyl)adamantane

生成物 1

HCID 21039691-(Chloromethyl)adamantane収率 91%

試薬・触媒・溶媒 2

HCID 3007855Zincchloride触媒HCID 10421208Zinc bromide触媒

実験手順

Chlorination reaction of 1-adamantyl methylalcohol which was obtained by the same method described in (1) was carried out under the same conditions for the bromination reaction shown in (2) except that zinc bromide and hydrobromic acid were replaced by zinc chloride and hydrochloric acid respectively. The product was purified by recrystallized from methanol. Melting point of 1-adamantyl methyl chloride thus obtained was 32°-34° C and the yield was 91%.

後処理

  1. customwas obtained by the same method
  2. customwas carried out under the same conditions for the bromination reaction
  3. customThe product was purified
  4. customby recrystallized from methanol

出典と根拠

ORDレコード
ord-fbbd2f48596345ff98bd1e3f739e32b8
出典データセット
uspto-grants-1977_01
特許番号
US04001223

関連ノート

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