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3-Chloropropyl(diethyl)amine → 3-p-Toluoyl-2-[4-(3-diethylaminopropoxy)phenyl]benzofuran

HRID 1414604
ノート
印刷プレビュー

反応式

HRID 1414604 の反応式
[Na].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[CH:26]=[CH:25][CH:24]=[CH:23][C:12]=3[C:13]=2[C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[CH2:27]([N:29]([CH2:34][CH3:35])[CH2:30][CH2:31][CH2:32]Cl)[CH3:28]>C1(C)C=CC=CC=1.CO>[CH2:27]([N:29]([CH2:34][CH3:35])[CH2:30][CH2:31][CH2:32][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:10][C:11]3[CH:26]=[CH:25][CH:24]=[CH:23][C:12]=3[C:13]=2[C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)=[CH:7][CH:8]=1)[CH3:28]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 669183-Chloropropyl(diethyl)amineHCID 5360545SodiumHCID 214879512-p-Hydroxyphenyl-3-p-methylbenzoylbenzofuran

生成物 1

HCID 103677653-p-Toluoyl-2-[4-(3-diethylaminopropoxy)phenyl]benzofuran

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 1140Toluene
溶媒
2 回

実験手順

To a solution of 0.177 g. (7.7 g.-atom) of sodium dissolved in 25 ml. of dry methanol was added a solution of 2.4 g. (7.3 mmol.) of 2-p-hydroxyphenyl-3-p-methylbenzoylbenzofuran in 75 ml. of toluene and 10 ml. of methanol. The mixture was refluxed for 15 minutes, then the methanol was removed by distillation. A solution of 1.15 g. (7.7 mmol.) of 3-diethylaminopropyl chloride in 25 ml. of toluene was then added and the resulting mixture was refluxed for 6 hours. After cooling, the reaction mixture was filtered and the filtrate was concentrated to give the title compound.

後処理

  1. temperatureThe mixture was refluxed for 15 minutes
  2. customthe methanol was removed by distillation
  3. temperaturethe resulting mixture was refluxed for 6 hours
  4. temperatureAfter cooling
  5. filtrationthe reaction mixture was filtered
  6. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-d08a998f14d34d68b027e1aa84a112db
出典データセット
uspto-grants-1977_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04001426

反応ノート

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