Epichlorohydrin → HCID 21487960、化合物

HRID 1414619ノート

反応式

HRID 1414619 の反応式
[OH-].[Na+].[C:3]([C:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[O:13][C:12]=1[C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1)(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH2:27]([CH:29]1[O:31][CH2:30]1)Cl>>[C:3]([C:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[O:13][C:12]=1[C:20]1[CH:21]=[CH:22][C:23]([O:26][CH2:27][CH:29]2[O:31][CH2:30]2)=[CH:24][CH:25]=1)(=[O:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 3

HCID 7835EpichlorohydrinHCID 14798Sodium HydroxideHCID 13264989[2-(4-Hydroxyphenyl)-1-benzofuran-3-yl](phenyl)methanone

生成物 1

HCID 21487960HCID 21487960、化合物

実験手順

To a mixture of 1.6 g. (0.04 mol.) of sodium hydroxide and 3.7 g. (0.012 mol.) of 3-benzoyl-2-p-hydroxyphenylbenzofuran was added with stirring 10.2 g. (0.11 mol.) of epichlorohydrin. The reaction mixture was refluxed for 1.5 hours, then it was cooled and extracted with methylene chloride. The extract was dried (MgSO4) and concentrated to give a residue which, after chromatography, gave 3-benzoyl-2-[4'-(2,3-epoxypropoxy)phenyl]benzofuran.

後処理

  1. additionTo a mixture of 1.6 g
  2. temperatureThe reaction mixture was refluxed for 1.5 hours
  3. temperatureit was cooled
  4. extractionextracted with methylene chloride
  5. dry with materialThe extract was dried (MgSO4)
  6. concentrationconcentrated
  7. customto give a residue which

出典と根拠

ORDレコード
ord-bfb76981e72644e185d32e8815f122aa
出典データセット
uspto-grants-1977_01
特許番号
US04001426

反応ノート

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