Phosgene → 1-Chlorocarbonyl-2-methyl-decahydro-quinoline

HRID 1414689ノート

反応式

HRID 1414689 の反応式
[NH:1]1[CH:11]2[CH:6]([CH2:7][CH2:8][CH2:9][CH2:10]2)[CH2:5][CH2:4][CH:2]1[CH3:3].[OH-].[Na+].[C:14](Cl)([Cl:16])=[O:15]>C(OCC)C.O>[Cl:16][C:14]([N:1]1[CH:11]2[CH:6]([CH2:7][CH2:8][CH2:9][CH2:10]2)[CH2:5][CH2:4][CH:2]1[CH3:3])=[O:15]

参加物

6

反応物 3

HCID 6371PhosgeneHCID 14798Sodium HydroxideHCID 5240162-Methyldecahydroquinoline (mixture of isomers)

生成物 1

HCID 214845771-Chlorocarbonyl-2-methyl-decahydro-quinoline

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 15 g decahydro-quinaldine dissolved in 200 ml of diethylether and 4 g of sodium hydroxide in 50 ml of water is reacted while stirring and cooling at -5° to 0° with 10 g of phosgene. An ethereal solution of 1-chlorocarbonyl-2-methyl-decahydro-quinoline is obtained. When an aqueous solution of 8.4 g of sodium ethylmercaptide is added to the ethereal solution at room temperature with stirring, 16 g of an almost colorless oil are obtained. The physical constants of this oil coincide with those of the compound of Example 1.

出典と根拠

ORDレコード
ord-98563a91d997454d88e9cc14114bfc6b
出典データセット
uspto-grants-1977_01
特許番号
US04002461

反応ノート

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