Ethanolamine → N-(2-hydroxyethyl) tetrabromophthalimide

HRID 1415108ノート

反応式

HRID 1415108 の反応式
[Br:1][C:2]1[C:3]([Br:15])=[C:4]([Br:14])[C:5]([Br:13])=[C:6]2[C:11](=[O:12])[O:10][C:8](=O)[C:7]=12.[CH2:16]([CH2:18][NH2:19])[OH:17].O>C1(C)C(C)=CC=CC=1>[OH:17][CH2:16][CH2:18][N:19]1[C:8](=[O:10])[C:7]2=[C:2]([Br:1])[C:3]([Br:15])=[C:4]([Br:14])[C:5]([Br:13])=[C:6]2[C:11]1=[O:12]

参加物

5

反応物 3

HCID 700EthanolamineHCID 962Water2 回HCID 12443Tetrabromophthalic anhydride

生成物 1

HCID 19812166N-(2-hydroxyethyl) tetrabromophthalimide

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

To a suspension of 464 gm (1 mole) of tetrabromophthalic anhydride in 1.2 liters of xylene was added 61 gm (1 mole) of ethanolamine. The solution was heated and refluxed with a Dean-Stark water separator until the theoretical amount of water separated. The mixture was cooled, diluted with hexane, and filtered. The resulting 413 gm of an off-white solid was washed with hexane and dried at 100° C. This material is used as is for subsequent reactions without further purification.

後処理

  1. temperatureThe solution was heated
  2. customseparated
  3. temperatureThe mixture was cooled
  4. additiondiluted with hexane
  5. filtrationfiltered
  6. washThe resulting 413 gm of an off-white solid was washed with hexane
  7. customdried at 100° C
  8. customas is for subsequent reactions without further purification

出典と根拠

ORDレコード
ord-28ab706dc0ad4f999b63ddaea580c57f
出典データセット
uspto-grants-1977_01
特許番号
US04003862

反応ノート

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