Ethanol → N-Hydroxy-4-nitrobenzimidamide

HRID 1415128

反応式

HRID 1415128 の反応式
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.[NH2:13][OH:14].C([O-])([O-])=O.[K+].[K+].C(O)C>O>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8](=[N:13][OH:14])[NH2:9])=[CH:10][CH:11]=1)([O-:3])=[O:2]

参加物

6

反応物 4

HCID 702EthanolHCID 11430Potassium CarbonateHCID 120904-NitrobenzonitrileHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 3825473N-Hydroxy-4-nitrobenzimidamide

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A solution of 29.6 g. (0.20 mole) of p-nitrobenzonitrile, 13.9 g. (0.20 mole) of hydroxylamine HCl, 13.8 g. (0.10 mole) of K2CO3 in 700 ml. of ethanol and 70 ml. of water is refluxed for 20 hours, cooled and diluted with 200 ml. of water. After removal of the ethanol by distillation in vacuo, the product is collected by filtration, washed with water and dried to yield 21.6 g. (60%).

後処理

  1. temperaturecooled
  2. additiondiluted with 200 ml
  3. customAfter removal of the ethanol
  4. distillationby distillation in vacuo
  5. filtrationthe product is collected by filtration
  6. washwashed with water
  7. customdried
  8. customto yield 21.6 g

出典と根拠

ORDレコード
ord-474104b62e4647feaae5889c7d14df53
出典データセット
uspto-grants-1977_01
特許番号
US04003909

関連ノート

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