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Benzoyl chloride → 3-(4-Nitrophenyl)-5-phenyl-1,2,4-oxadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | Boron trifluoride etherate | HCID 8000 | — |
| 反応物 | N-Hydroxy-4-nitrobenzimidamide | HCID 3825473 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 3-(4-Nitrophenyl)-5-phenyl-1,2,4-oxadiazole | HCID 622484 | — |
反応手順
A solution of 10.8 g. (0.06 mole) of p-nitrobenzamidoxime and 8.5 g. (0.06 mole) of benzoyl chloride in 250 ml. of dioxane is heated on a steam bath for one hour, followed by the addition of 2 ml. of BF3 -Et2O. After refluxing the solution overnight, the reaction mixture is cooled and the material which precipitates is collected by filtration to yield 8.1 g. (50%) of 5-phenyl-3-(4-nitrophenyl)-1,2,4-oxadizole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04003909 |
| 出典データセット | uspto-grants-1977_01 |
| ORD ID | ord-901ed1a1bcc743e1b1f1eb34e496da21 |
| 出典メモ | uspto-grants-1977_01 |