反应详情

A solution of 10.8 g. (0.06 mole) of p-nitrobenzamidoxime and 8.5 g. (0.06 mole) of benzoyl chloride in 250 ml. of dioxane is heated on a steam bath for one hour, followed by the addition of 2 ml. of BF3 -Et2O. After refluxing the solution overnight, the reaction mixture is cooled and the material which precipitates is collected by filtration to yield 8.1 g. (50%) of 5-phenyl-3-(4-nitrophenyl)-1,2,4-oxadizole.

1. additionfollowed by the addition of 2 ml
2. temperatureAfter refluxing the solution overnight
3. temperaturethe reaction mixture is cooled
4. customthe material which precipitates
5. filtrationis collected by filtration
6. customto yield 8.1 g