N-Methylhomoveratrylamine → HCID 86734429、化合物

HRID 1415272ノート

反応式

HRID 1415272 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]1(C2C=CC(OC)=C(OC)C=2)[S:10](=[O:12])(=[O:11])[CH2:9][CH2:8][CH2:7][S:6]1(=[O:14])=[O:13].[CH3:25][NH:26]CCC1C=CC(OC)=C(OC)C=1.C(N(C(C)C)C(C)C)C>CN(C)C=O>[ClH:1].[CH3:25][NH:26][CH2:2][CH2:3][CH2:4][CH:5]1[S:10](=[O:12])(=[O:11])[CH2:9][CH2:8][CH2:7][S:6]1(=[O:14])=[O:13]

参加物

5

反応物 3

HCID 77039N-MethylhomoveratrylamineHCID 81531DiisopropylethylamineHCID 12462834HCID 12462834、化合物

生成物 1

HCID 86734429HCID 86734429、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
120 °C

実験手順

10.4 g of 2-(3-chloropropyl)-2-(3,4-dimethoxyphenyl)-m-dithiane-1,1,3,3-tetraoxide are treated with 5.11 g of N-methyl-homoveratrylamine, 30 ml of N-ethyl-N,N-diisopropylamine and 70 ml of dimethylformamide. The solution is heated at 120° C for 6 hours. After evaporation, the residue is worked-up in a manner analogous to that described in Example 5. There is obtained N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl(-N-methyl-m-dithiane-2-propylamine-1,1,3,3-tetraoxide hydrochloride of melting point 167°-169° C.

後処理

  1. customAfter evaporation

出典と根拠

ORDレコード
ord-fe485c9669364a038bf59e00164e8383
出典データセット
uspto-grants-1977_01
特許番号
US04003914

反応ノート

読み込み中…