Acetic Acid → HCID 12491129、化合物

HRID 1415433ノート

反応式

HRID 1415433 の反応式
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4](S(O)(=O)=O)=[CH:3][CH:2]=1.[C:12]([OH:15])(=[O:14])[CH3:13].C(OC(=O)C)(=O)C.[CH:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:1]12[CH2:11][CH2:13][C:12](=[O:15])[O:14][C:26]=1[CH2:25][CH2:24][CH2:23][CH2:28][CH2:27][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2

参加物

5

反応物 4

HCID 176Acetic AcidHCID 241BenzeneHCID 6101p-Toluenesulfonic acidHCID 7918Acetic Anhydride

生成物 1

HCID 12491129HCID 12491129、化合物収率 32.8%

実験手順

Five parts of the foregoing β-(2-oxocyclododecyl)propionic acid morpholine amide, 0.2 part of paratoluene sulfonic acid, 50 parts of acetic acid, and 5 parts of acetic anhydride were refluxed for 36 hours. And then 300 parts of benzene was added into the solution and washed with aqueous sodium bicarbonate to remove the catalyst and acetic acid. Thereafter, the resulting solution was treated by the same method as described in Example 1 to give 1.54 parts of 13-oxabicyclo(10.4.0)hexadec-1(12)-en-14-one in 32.8% yield.

後処理

  1. washwashed with aqueous sodium bicarbonate
  2. customto remove the catalyst and acetic acid
  3. additionThereafter, the resulting solution was treated by the same method

出典と根拠

ORDレコード
ord-984e58c06d634459a47bef58b3326a8b
出典データセット
uspto-grants-1977_01
特許番号
US04005107

反応ノート

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