Hydrochloric Acid → 1,2-Diamino-4-(pyrimidin-2-ylthio)benzene

HRID 1415526

反応式

HRID 1415526 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([S:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH:5]=[CH:4][C:3]=1[N+:15]([O-])=O.Cl.C(=O)(O)[O-].[K+]>C(Cl)(Cl)Cl>[NH2:15][C:3]1[CH:4]=[CH:5][C:6]([S:8][C:9]2[N:10]=[CH:11][CH:12]=[CH:13][N:14]=2)=[CH:7][C:2]=1[NH2:1]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 516893Potassium BicarbonateHCID 214827752-Nitro-5-[(pyrimidin-2-yl)sulfanyl]aniline

生成物 1

HCID 214827791,2-Diamino-4-(pyrimidin-2-ylthio)benzene

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

3.5 G. of 2-amino-1-nitro-4-(pyrimidin-2-ylthio)benzene is treated with 16 g. stannous chloride in 16 ml. concentrated hydrochloric acid on the steam bath for 30 minutes. The mixture is cooled, treated with an excess of potassium bicarbonate, chloroform, and filtered. The chloroform layer is dried and stripped yielding 1,2-diamino-4-(pyrimidin-2-ylthio)benzene which may be recrystallized from benzene.

後処理

  1. temperatureThe mixture is cooled
  2. filtrationfiltered
  3. dry with materialThe chloroform layer is dried

出典と根拠

ORDレコード
ord-9e608459653b47e88ce7dbe770e09bbd
出典データセット
uspto-grants-1977_01
特許番号
US04005202

関連ノート

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