Methylamine → HCID 21482809、化合物

HRID 1415545

反応式

HRID 1415545 の反応式
[H][H].[CH2:3]([N:5]1[CH2:10][CH2:9][CH2:8][C:7](=O)[CH2:6]1)[CH3:4].[CH3:12][NH2:13]>[Pt](=O)=O.CO>[CH2:3]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([NH:13][CH3:12])[CH2:6]1)[CH3:4]

参加物

6

反応物 3

HCID 6329MethylamineHCID 4334391-Ethylpiperidin-3-one hydrochlorideHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 21482809HCID 21482809、化合物

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

A suspension of 0.25 g. of platinum dioxide in 20 ml. of methanol was shaken under 30 p.s.i. of hydrogen for one hour. To this activated catalyst was added a solution of 7.9 g. (48 mmoles) of 1-ethyl-3-piperidone and 3.1 g. (100 mmoles) of methylamine in 40 ml. of methnol. This mixture was shaken under about 50 p.s.i. of hydrogen for 1.5 hours, then filtered. The solvent was distilled off the filtrate at atmospheric pressure. The residue was then distilled at reduced pressure to give 1-ethyl-3-methylaminopiperidine, b.p. 88°-90.5° C. at 28 mm.

後処理

  1. additionA suspension of 0.25 g
  2. additionTo this activated catalyst was added a solution of 7.9 g
  3. filtrationfiltered
  4. distillationThe solvent was distilled off the filtrate at atmospheric pressure
  5. distillationThe residue was then distilled at reduced pressure

出典と根拠

ORDレコード
ord-abf4998b4ba34c66bc8fbc364e15c119
出典データセット
uspto-grants-1977_01
特許番号
US04005208

関連ノート

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