Sodium hydride → HCID 20361951、化合物

HRID 1415594ノート

反応式

HRID 1415594 の反応式
[CH3:1][C:2]1[N:3]=[N:4][C:5](=[O:9])[C:6]=1[CH2:7][CH3:8].[H-].[Na+].[CH3:12][CH:13](Cl)[C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1>CN(C)C=O>[CH3:1][C:2]1[NH:3][N:4]([CH:13]([CH3:12])[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)[C:5](=[O:9])[C:6]=1[CH2:7][CH3:8]

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 1082961,2-Dichloro-4-(1-chloroethyl)benzeneHCID 54312548HCID 54312548、化合物

生成物 1

HCID 20361951HCID 20361951、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

25.2 g of 3-methyl-4-ethylpyrazol-5-one were added in portions to a suspension of 10.0 g (0.22 mol) of sodium hydride in 200 ml of absolute dimethylformamide. After the evolution of H2 had ceased, 41.8 g (0.2 mol) of α-methyl-3,4-dichlorobenzyl chloride were added dropwise to the reaction solution. The mixture was then stirred for 2 hours at 60° C, the solvent was distilled off in vacuo and the residue was taken up in water and acidified with dilute acetic acid. The crude product thereby obtained was recrystallized from ethanol.

後処理

  1. distillationthe solvent was distilled off in vacuo

出典と根拠

ORDレコード
ord-f821f5ac53d245bbb8e2fadeb511e98c
出典データセット
uspto-grants-1977_01
特許番号
US04005215

反応ノート

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