Hydrogen Bromide → 6-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

HRID 1416

反応式

HRID 1416 の反応式
C([O:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[C:17]([C:22]([OH:24])=[O:23])[CH:16]=[CH:15]2)CCCCCCCCC.Br>C(O)(=O)C>[OH:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH2:18][CH:17]([C:22]([OH:24])=[O:23])[CH2:16][CH2:15]2

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 103591672-Naphthalenecarboxylic acid, 6-(decyloxy)-

生成物 1

HCID 190700016-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid収率 100%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

16.6 g (50 mmol) of the 6-decyloxynaphthalene-2-carboxylic acid obtained in the first stage was heated under reflux at 130° C. for 7 hours in the presence of 250 cc of acetic acid and 86.5 g (0.5 mol) of 47% hydrobromic acid. To the reaction mixture was added distilled water, and then the resulting mixture was concentrated under reduced pressure to obtain 10.60 g (50 mmol) of 1,2,3,4-tetrahydro-6-hydroxynaphthalene-2-carboxylic acid.

後処理

  1. temperaturewas heated
  2. additionTo the reaction mixture was added
  3. distillationdistilled water
  4. concentrationthe resulting mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-528cd02b7f3644e7b8e580a1f266c8a1
出典データセット
uspto-grants-1998_03
特許番号
US05725798

関連ノート

読み込み中…