HCID 67581934、化合物 → HCID 54302337、化合物
反応式
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[N:26]=[C:25]([O:27][CH2:28][C@@H:29]([OH:33])[C@H:30]([OH:32])[CH3:31])[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CO.[Pd]>[OH:33][C@@H:29]([C@H:30]([OH:32])[CH3:31])[CH2:28][O:27][C:25]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=[C:17]([N:14]2[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]2)[N:26]=1参加物
4
実験手順
2-[4-(Benzyloxycarbonyl)piperazin-1-yl]-4-[(2R,3R)-(2,3-dihydroxybutan-1-yl)oxy]quinazoline (1.3 g) is dissolved in methanol (20 ml), and thereto is added 10% palladium/carbon (0.4 g), and the mixture is stirred under hydrogen atmosphere and under atmospheric pressure at room temperature for 16 hours. The reaction mixture is filtered, and the filtrate is evaporated to dryness under reduced pressure to give 4-[(2R,3R)-(2,3-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (0.9 g).