2-Propanaminium, N,N,N-tris(1,1-dimethylethyl)-2-methyl-, fluoride → 3-((trans-4-hydroxy-2-(S)-pyrrolidinyl)methoxy)pyridine
反応式
Cl.Cl.[OH:3][C@H:4]1[CH2:8][NH:7][C@H:6]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=CN=2)[CH2:5]1.[F-].[C:18]([N+:22](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C)(C)C>C1COCC1>[OH:3][C@H:4]1[CH2:8][NH:7][C@H:6]([CH2:9][O:10][C:11]2[CH:18]=[N:22][CH:14]=[CH:15][CH:16]=2)[CH2:5]1参加物
4
実験手順
A 1.35 g sample of the compound from step 72d above was dissolved in 9 mL of THF and 9.3 mL of tetra-(t-butyl)ammonium fluoride was added. The reaction mixture was stirred at room temperature for 16 hours, and the volatiles were removed under vacuum. The residue was purified on silica gel, eluting with 3:1 ethyl acetate:hexane, to give the title compound.
後処理
- customthe volatiles were removed under vacuum
- customThe residue was purified on silica gel
- washeluting with 3:1 ethyl acetate
出典と根拠
- ORDレコード
- ord-78fc82dea4fe4ac29c88121716436574
- 出典データセット
- uspto-grants-1999_06
- 特許番号
- US05914328
反応ノート
読み込み中…