HCID 9926017、化合物 → 1-(2-Methylphenyl)-4-oxo-6-methyl-4,5-dihydropyrrolo[3,2-c]quinoline

HRID 1416679ノート

反応式

HRID 1416679 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:21])[C:14]=3[NH:13][C:12](=[O:22])[C:11]=2[CH2:10][CH2:9]1>C1(OC2C=CC=CC=2)C=CC=CC=1.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:21])[C:14]=3[NH:13][C:12](=[O:22])[C:11]=2[CH:10]=[CH:9]1

参加物

4

反応物 1

HCID 9926017HCID 9926017、化合物

生成物 1

HCID 157498281-(2-Methylphenyl)-4-oxo-6-methyl-4,5-dihydropyrrolo[3,2-c]quinoline収率 85%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 7583Diphenyl Ether溶媒

実験手順

1-(2-methylphenyl)-4-oxo-6-methyl-2,3,4,5-tetra hydropyrrolo[3,2-c]quinoline (290 mg, 1.0 mmol) was dissolved in 20 ml of diphenyl ether and 40 mg of 5% palladium/carbon was added. The reaction mixture was heated for 4 hours. The reaction mixture was cooled to the room temperature and directly purified by silica gel chromatography to obtain 245 mg of desired compound as solid in 85% of yield.

後処理

  1. temperatureThe reaction mixture was heated for 4 hours
  2. customdirectly purified by silica gel chromatography

出典と根拠

ORDレコード
ord-eb7118dd4a19490585f202b86d2c4d03
出典データセット
uspto-grants-1999_06
特許番号
US05914402

反応ノート

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