Hydrogen Bromide → 3-Phenoxyphenol

HRID 1416949ノート

反応式

HRID 1416949 の反応式
[O:1]([C:8]1[CH:9]=[C:10]([O:14]C)[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br>C(O)(=O)C>[O:1]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 742521-Methoxy-3-phenoxybenzene

生成物 1

HCID 128423-Phenoxyphenol

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

3-Phenoxyanisole (8.3 g) was added to a mixture of 50 mL of 40% HBr and 100 mL of glacial acetic acid. The resultant mixture was heated under reflux for 48 hours, then cooled and concentrated under reduced pressure. The residue was taken up in EtOAc, washed with water, saturated NaHCO3, and brine. After drying with MgSO4, and concentration under reduced pressure, 3-phenoxyphenol was obtained and used without further purification.

後処理

  1. temperatureunder reflux for 48 hours
  2. temperaturecooled
  3. concentrationconcentrated under reduced pressure
  4. washwashed with water, saturated NaHCO3, and brine
  5. dry with materialAfter drying with MgSO4, and concentration under reduced pressure

出典と根拠

ORDレコード
ord-f89d7d897c4d4a39a8c7436c257186e9
出典データセット
uspto-grants-1999_06
特許番号
US05916922

反応ノート

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