Methanol → E-5-Decen-1-ol

HRID 1416986

反応式

HRID 1416986 の反応式
C([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH3:14])(=O)C.CO.[OH-].[Na+]>CCCCCC>[CH2:5]([OH:4])[CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH3:14]

参加物

5

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 38027Dec-5-enyl acetate

生成物 1

HCID 92458E-5-Decen-1-ol収率 89.8%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

A portion of the acetate is removed and converted to the corresponding alcohol as follows. 15.0 g (67 mmol) of the 5-decenyl acetate, 35 mL of methanol and 34 mL of 2 M sodium hydroxide were added to a 250 mL round-bottomed flask. This mixture was stirred for 3 hours at room temperature. After 3 hours the hydrolysis was complete, 10 mL of hexane was added and the solution was washed with 10 mL of 1 M HCl, 10 mL of NaHCO3 -saturated water and 10 mL of brine. The organic phase was dried with sodium sulfate, filtered and the hexane removed under reduced pressure to yield 9.4 g of 5-decenol. GC analysis showed the isometric ratio to be 80:20 E:Z.

後処理

  1. customA portion of the acetate is removed
  2. waitAfter 3 hours the hydrolysis was complete
  3. washthe solution was washed with 10 mL of 1 M HCl, 10 mL of NaHCO3 -saturated water and 10 mL of brine
  4. dry with materialThe organic phase was dried with sodium sulfate
  5. filtrationfiltered
  6. customthe hexane removed under reduced pressure

出典と根拠

ORDレコード
ord-a6bfda5146ce4928a76fc0c336283733
出典データセット
uspto-grants-1999_06
特許番号
US05916983

関連ノート

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