8-Cyano-octanoic acid → 9-Aminononanoic acid

HRID 1417049

反応式

HRID 1417049 の反応式
[C:1]([CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])#[N:2]>C(O)(C)C.N.[Co]>[NH2:2][CH2:1][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11]

参加物

5

反応物 1

HCID 110843008-Cyano-octanoic acid

生成物 1

HCID 1368779-Aminononanoic acid収率 92.5%

試薬・触媒・溶媒 3

HCID 104730Cobalt触媒HCID 222Ammonia溶媒HCID 3776Isopropanol溶媒

実験手順

84.5 g of 8-cyanooctanoic acid dissolved in 500 ml of isopropyl alcohol saturated with NH3 are hydrogenated at 50° C. and 80 bar for 3 hours, using 20 g of cobalt-Raney as catalyst. The catalyst is filtered out and the solution is concentrated. Cooling and purification produce 9-aminononanoic acid (80 g) in the form of a crystalline solid product with a m.p. of 190-192° C.

後処理

  1. customare hydrogenated at 50° C.
  2. filtrationThe catalyst is filtered out
  3. concentrationthe solution is concentrated
  4. temperatureCooling
  5. custompurification

出典と根拠

ORDレコード
ord-1b028e65be614122ad30c0bf9ba1a2f2
出典データセット
uspto-grants-1999_06
特許番号
US05917067

関連ノート

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