Formamide → 2-[4-[4-(Pyrimidin-4-yl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione

HRID 1417318

反応式

HRID 1417318 の反応式
[C:1]([C:4]1[CH:25]=[CH:24][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]2=[O:23])=[CH:6][CH:5]=1)(=O)[CH3:2].[CH:26]([NH:28][CH:29](NC=O)[NH:30]C=O)=O.C(N)=O.[OH-].[Na+]>O>[N:28]1[CH:26]=[CH:2][C:1]([C:4]2[CH:25]=[CH:24][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]3[C:21](=[O:22])[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[C:14]3=[O:23])=[CH:6][CH:5]=2)=[N:30][CH:29]=1

参加物

6

反応物 4

HCID 713FormamideHCID 14798Sodium HydroxideHCID 78505N,N',N''-MethylidynetrisformamideHCID 675980872-[4-(4-Acetylphenoxy)butyl]-1H-isoindole-1,3(2H)-dione

生成物 1

HCID 675995062-[4-[4-(Pyrimidin-4-yl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 10.0 g of 2-[4-(4-acetylphenoxy]-butyl]-1H-isoindole-1,3(2H)-dione (Example 42) 10.0 g of tris(formamido)methane, and 20 ml of formamide are combined and the mixture stirred and heated at 160°-165° C. for 8 hours. After dilution with 100 ml of water, the mixture is rendered basic with 10N NaOH, the precipitate collected, washed with water, and air dried. Recrystallization from ethanol gives the pure compound, m.p. 100°-102° C.; yield, 5.0 g.

後処理

  1. temperatureheated at 160°-165° C. for 8 hours
  2. customthe precipitate collected
  3. washwashed with water, and air
  4. customdried
  5. customRecrystallization from ethanol
  6. customgives the pure compound, m.p. 100°-102° C.
  7. customyield

出典と根拠

ORDレコード
ord-14a0374f1cf0424bb6cd26c83a98c3ef
出典データセット
uspto-grants-1999_03
特許番号
US05877196

関連ノート

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