4-Methylmorpholine → 8-(t-Butoxycarbonyl)amino-octanoic acid methyl-butyl-amide

HRID 1417419ノート

反応式

HRID 1417419 の反応式
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].CN1CCOCC1.Cl.CN(C)CCCN=C=NCC.Cl.[CH3:39][NH:40][CH2:41][CH2:42][CH2:43][CH3:44].O.OC1C2N=NNC=2C=CC=1>ClCCl.O>[CH3:39][N:40]([CH2:41][CH2:42][CH2:43][CH3:44])[C:16](=[O:18])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7]

参加物

8

反応物 5

HCID 79724-MethylmorpholineHCID 5462158-(((Tert-butoxy)carbonyl)amino)octanoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 6337757N-methylbutylamine hydrochlorideHCID 178526939HCID 178526939、化合物

生成物 1

HCID 537219698-(t-Butoxycarbonyl)amino-octanoic acid methyl-butyl-amide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

Combine 8-(t-butoxycarbonyl)amino-octanoic acid (1.28 g, 5 mmol), N-methylmorpholine (1.2 mL, 10 mmol), 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride salt (0.95 g, 5.0 mmol), methyl-butyl amine hydrochloride salt (5.0 mmol), and 4-hydroxybenztriazole hydrate (0.05 g) in dichloromethane (20 mL). After 4 hours, add water and extract with ethyl acetate. Dry the organic layer over MgSO4 and evaporate in vacuo to give the title compound.

後処理

  1. extractionextract with ethyl acetate
  2. dry with materialDry the organic layer over MgSO4
  3. customevaporate in vacuo

出典と根拠

ORDレコード
ord-d97eb11b1d854ecfac8ea4633b8374a2
出典データセット
uspto-grants-1999_03
特許番号
US05877202

反応ノート

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