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Hydrochloric Acid → 6-benzyloxy-4-methoxymethyl-9-{6-[N-methyl-N-(2-phenylethyl)-amino]-2-oxohexyl}-9H-pyrido-[3,4-b]-indole-3-carboxylic acid

HRID 1417963
ノート
印刷プレビュー

反応式

HRID 1417963 の反応式
CC([O:4][C:5]([C:7]1[N:44]=[CH:43][C:10]2[N:11]([CH2:26][C:27](=[O:42])[CH2:28][CH2:29][CH2:30][CH2:31][N:32]([CH3:41])[CH2:33][CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[C:12]3[C:17]([C:9]=2[C:8]=1[CH2:45][O:46][CH3:47])=[CH:16][C:15]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[CH:14][CH:13]=3)=[O:6])C.[OH-].[Na+].Cl>CO>[CH2:19]([O:18][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[N:11]([CH2:26][C:27](=[O:42])[CH2:28][CH2:29][CH2:30][CH2:31][N:32]([CH3:41])[CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:10]1[CH:43]=[N:44][C:7]([C:5]([OH:6])=[O:4])=[C:8]([CH2:45][O:46][CH3:47])[C:9]2=1)[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 867538596-benzyloxy-4-methoxymethyl-9{6-[N-methyl-N-(2-phenylethyl)-amino]-2-oxohexyl}9H-pyrido[3,4-b]indole-3-carboxylic acid-(1-methylethyl)-ester

生成物 1

HCID 442135056-benzyloxy-4-methoxymethyl-9-{6-[N-methyl-N-(2-phenylethyl)-amino]-2-oxohexyl}-9H-pyrido-[3,4-b]-indole-3-carboxylic acid収率 64.9%

試薬・触媒・溶媒 1

HCID 887
Methanol
溶媒

実験手順

350 mg of 6-benzyloxy-4-methoxymethyl-9-{6-[N-methyl-N-(2-phenylethyl)-amino]-2-oxohexyl}-9H-pyrido[3,4-b]indole-3-carboxylic acid-(1-methylethyl)-ester (0.55 mmol) is mixed in 10 ml of methanol with 1 ml of 2N aqueous sodium hydroxide solution and held at 40° C. until the reaction is completed. Then, the reaction mixture is acidified with dilute hydrochloric acid, and the precipitated product is suctioned off. It is washed with water and then with diethyl ether, dried in a vacuum, and 212 mg of 6-benzyloxy-4-methoxymethyl-9-{6-[N-methyl-N-(2-phenylethyl)-amino]-2-oxohexyl}-9H-pyrido-[3,4-b]-indole-3-carboxylic acid is obtained as a yellow, amorphous powder.

後処理

  1. customheld at 40° C. until the reaction
  2. washIt is washed with water
  3. dry with materialwith diethyl ether, dried in a vacuum

出典と根拠

ORDレコード
ord-147b6912136349b2b8a9803151fcff91
出典データセット
uspto-grants-1999_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05880126

反応ノート

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