Sodium Hydroxide → 2-chloro-4-(2-2H-1,2,3-triazolylmethyl)phenol

HRID 1418719ノート

反応式

HRID 1418719 の反応式
CC(C)(C)C([O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[N:17]=[CH:16][CH:15]=[N:14]2)=[CH:8][C:7]=1[Cl:18])=O.[OH-].[Na+]>C(O)C>[Cl:18][C:7]1[CH:8]=[C:9]([CH2:12][N:13]2[N:17]=[CH:16][CH:15]=[N:14]2)[CH:10]=[CH:11][C:6]=1[OH:5]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 53869820HCID 53869820、化合物

生成物 1

HCID 218336772-chloro-4-(2-2H-1,2,3-triazolylmethyl)phenol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 3 g of 2-chloro-4-(2-2H-1,2,3-triazolyl)methylphenyl 2,2-di-methylpropanoate, 10 ml of 20% aqueous sodium hydroxide solution and 60 ml of ethanol was heated at reflux for 5 hours. The reaction mixture was then concentrated under reduced pressure, to which water was added, and the mixture was adjusted to pH 6.0 with concentrated hydrochloric acid. This mixture was extracted with ethyl acetate. The organic layer was washed with water, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, which afforded 2-chloro-4-(2-2H-1,2,3-triazolylmethyl)phenol.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 5 hours
  3. concentrationThe reaction mixture was then concentrated under reduced pressure, to which water
  4. additionwas added
  5. extractionThis mixture was extracted with ethyl acetate
  6. washThe organic layer was washed with water
  7. dry with materialdried with anhydrous magnesium sulfate
  8. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-78d26d8ca1f74a78be6a2dd0d6b84b36
出典データセット
uspto-grants-1999_03
特許番号
US05883262

反応ノート

読み込み中…