1-Propanol → HCID 131720992、化合物

HRID 1418799ノート

反応式

HRID 1418799 の反応式
[O:1]=[C:2]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH3:14])=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4].O.[C:16]1(C)[CH:21]=CC(S(O)(=O)=O)=C[CH:17]=1.C1(C)C=CC=CC=1.CCCO>O>[CH2:17]([O:4][C:3](=[O:5])[C:2]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH3:14])=[CH:8][CH:7]=1)=[O:1])[CH2:16][CH3:21]

参加物

6

反応物 4

HCID 10311-PropanolHCID 1140TolueneHCID 521998p-Toluenesulfonic acid monohydrateHCID 50548412-(4-Ethoxyphenyl)-2-oxoacetic acid

生成物 1

HCID 131720992HCID 131720992、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

10.4 g (50 mmol) of α-oxo-4-ethoxyphenylacetic acid (Bandyopahyay et al., J. Ind. Chem. Soc. 66(4), 239, 1989) and 1.0 g of p-toluenesulfonic acid-monohydrate are refluxed into a mixture of 100 ml of toluene and 50 ml of N-propanol while in a water separator until no more water separates out. Then, it is concentrated by evaporation in a vacuum, the residue is dispersed between ethyl acetate and sodium bicarbonate solution, the organic phase is dried on magnesium sulfate, filtered and concentrated by evaporation.

後処理

  1. concentrationThen, it is concentrated by evaporation in a vacuum
  2. additionthe residue is dispersed between ethyl acetate and sodium bicarbonate solution
  3. customthe organic phase is dried on magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-4fb444f1d22d4e30bd56431180d64251
出典データセット
uspto-grants-1999_03
特許番号
US05885548

反応ノート

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