Water → HCID 178418454、化合物

HRID 1419050

反応式

HRID 1419050 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([CH2:12][C:13]([CH3:16])([CH3:15])[CH3:14])[C:10](=[O:17])[C@@H:9]([CH2:18][C:19]([NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]#[N:29])[CH:23]=3)=[O:20])[O:8][C@H:7]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[Cl:36])[C:6]=2[CH:37]=1.[N-:38]=[N+:39]=[N-:40].[Na+].O>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([CH2:12][C:13]([CH3:14])([CH3:15])[CH3:16])[C:10](=[O:17])[C@@H:9]([CH2:18][C:19]([NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]4[NH:40][N:39]=[N:38][N:29]=4)[CH:23]=3)=[O:20])[O:8][C@H:7]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[Cl:36])[C:6]=2[CH:37]=1

参加物

5

反応物 3

HCID 962WaterHCID 33557Sodium AzideHCID 69946147trans-7-Chloro-5-(2-chlorophenyl)-3-(3-cyanophenylaminocarbonylmethyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine

生成物 1

HCID 178418454HCID 178418454、化合物収率 50.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 0.2 g of trans-7-chloro-5-(2-chlorophenyl)-3-(3-cyanophenylaminocarbonylmethyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine and 80 mg of sodium azide in 5 ml of dimethylformamide was stirred at 90° C. for 60 hours. After water was added, the mixture was washed with water, after which the solvent was removed and the residue was subjected to silica gel column-chromatography to yield 0.11 g of a crystal.

後処理

  1. washthe mixture was washed with water
  2. customafter which the solvent was removed

出典と根拠

ORDレコード
ord-f306cfa200ec46a6a1e0340bff629340
出典データセット
uspto-grants-1999_03
特許番号
US05885979

関連ノート

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